Description

Fibrinopeptide B, Des-Arg(14)- is a specific, enzymatically cleaved fragment of the fibrinogen beta chain, representing a key intermediate in the study of blood coagulation biochemistry. This peptide is crucial for researchers investigating the precise mechanisms of thrombin activity, fibrin formation, and the development of novel antithrombotic agents. It is primarily utilized by pharmaceutical R&D teams, clinical diagnostic developers, and academic biochemists focused on hemostasis and thrombosis.

Application

• Biochemical Research: Serves as a critical reference standard and substrate in studies of thrombin specificity and fibrinopeptide release kinetics.
• Diagnostic Development: Used in the calibration and validation of immunoassays (e.g., ELISA) designed to measure fibrinopeptide B levels as a marker for in vivo thrombin generation and thrombotic risk.
• Pharmaceutical R&D: Acts as a tool compound for screening and characterizing potential inhibitors of thrombin or other coagulation cascade enzymes.
• Proteomics & Biomarker Discovery: Employed as a known standard in mass spectrometry-based workflows to identify and quantify fibrinogen-derived peptides in complex biological samples.
• Enzyme Kinetics: Utilized to determine kinetic parameters (Km, kcat) for thrombin and related proteases, providing insights into enzyme mechanism and regulation.

Basic Information

Product Name	Fibrinopeptide B, Des-Arg(14)-
CAS No.	71494-32-1
Molecular Formula	C71H112N22O26S2
Molecular Weight	1681.9 g/mol
Synonyms	Des-Arg(14)-Fibrinopeptide B; Fibrinopeptide B (1-14); FPB (1-14); H-Gly-Val-Asn-Asp-Asn-Glu-Glu-Gly-Phe-Phe-Ser-Ala-Arg-OH; Human Fibrinopeptide B minus C-terminal Arginine; β-Fibrinopeptide (1-14)
EINECS	Contact for details

Quality Control

Our Fibrinopeptide B, Des-Arg(14)- is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is characterized using advanced analytical techniques including HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content is provided with every shipment, supporting compliance with rigorous laboratory standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.