Description

Ethyl 4-Amino-2-Chloropyrimidine-5-Carboxylate, also known as 4-Amino-2-Chloro-Pyrimidine-5-Carboxylic Acid Ethyl Ester, is a high-value pyrimidine derivative serving as a critical synthetic intermediate in advanced organic chemistry. Its molecular structure, featuring both amino and chloro substituents, makes it a versatile building block for constructing complex heterocyclic systems. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to synthesize novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of nucleoside analogs, kinase inhibitors, and other small-molecule drug candidates targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and plant growth regulators that require pyrimidine-based active ingredients.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Material Science: Investigated as a monomer or precursor for the development of specialty polymers and functional organic materials.
• Dye & Pigment Industry: Acts as an intermediate in the synthesis of complex heterocyclic dyes and colorants.

Basic Information

Product Name	Ethyl 4-Amino-2-Chloropyrimidine-5-Carboxylate
CAS No.	71406-78-5
Molecular Formula	C7H8ClN3O2
Molecular Weight	201.61 g/mol
Synonyms	4-Amino-2-chloropyrimidine-5-carboxylic acid ethyl ester; 2-Chloro-4-aminopyrimidine-5-carboxylic acid ethyl ester; Ethyl 4-amino-2-chloro-5-pyrimidinecarboxylate; 5-Carbethoxy-2-chloro-4-aminopyrimidine; 4-Amino-2-chloro-5-ethoxycarbonylpyrimidine; 71406-78-5; 2-Chloro-4-amino-5-pyrimidinecarboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 4-Amino-2-Chloropyrimidine-5-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our commitment to GMP principles and ISO standards ensures reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.