Description

4'-Deoxy-6'-n-Methylamikacin is a semi-synthetic derivative of the aminoglycoside antibiotic amikacin, designed to address specific resistance mechanisms. This compound is of significant interest in pharmaceutical research for the development of next-generation antibacterial agents with potentially improved efficacy and reduced toxicity profiles. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on advanced antibiotic synthesis and microbiological studies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the research and synthesis of novel aminoglycoside antibiotic candidates.
• Antimicrobial Research: Used in microbiological studies to investigate structure-activity relationships (SAR) against resistant bacterial strains.
• Biochemical Research: Employed as a reference standard or probe in studies of bacterial ribosome interaction and protein synthesis inhibition.
• Fine Chemical Synthesis: A critical intermediate for specialized chemical manufacturers producing high-value, research-grade compounds.

Basic Information

Product Name	4'-Deoxy-6'-n-Methylamikacin
CAS No.	71398-14-6
Molecular Formula	C22H45N5O12
Molecular Weight	571.62 g/mol
Synonyms	6'-N-Methyl-4'-deoxyamikacin; 4'-Deoxy-6'-N-methylamikacin; 1-N-[(S)-4-Amino-2-hydroxybutyryl]-6'-N-methyl-4'-deoxykanamycin A; Amikacin 4'-deoxy-6'-N-methyl derivative; Antibiotic BB-K 412
EINECS	Contact for details

Quality Control

Our 4'-Deoxy-6'-n-Methylamikacin is produced under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP guidelines for the manufacture of pharmaceutical intermediates, ensuring traceability and documentation for regulatory support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.