Description

Secretin, Val(5)- CAS NO 71376-01-7 is a synthetic analogue of the gastrointestinal peptide hormone secretin, specifically modified at the fifth amino acid position with valine. This modification can enhance the peptide's stability and receptor-binding specificity, making it a valuable tool for advanced biochemical and pharmacological research. It is primarily utilized by research institutions and pharmaceutical developers focused on endocrinology, digestive system studies, and the development of diagnostic agents.

Application

• Biomedical Research: Used as a critical reagent in studies investigating the physiological role of secretin in pancreatic bicarbonate secretion and gastric acid inhibition.
• Pharmacology Development: Serves as a reference standard or active pharmaceutical ingredient (API) in preclinical research for novel therapies targeting secretin receptors.
• Diagnostic Agent Formulation: Employed in the development and calibration of diagnostic kits for pancreatic function tests (e.g., secretin stimulation tests).
• Cell Signaling Studies: Applied in in vitro assays to study G-protein coupled receptor (GPCR) activation, intracellular signaling pathways, and cyclic AMP production.
• Peptide Chemistry & Stability Research: Acts as a model compound for studying the effects of amino acid substitutions on peptide stability, bioavailability, and metabolic clearance.

Basic Information

Product Name	Secretin, Val(5)-
CAS No.	71376-01-7
Molecular Formula	C130H220N44O41
Molecular Weight	3055.4 g/mol
Synonyms	Val5-Secretin; [Val5]-Secretin; Secretin (human) (Val5-analogue); Secretin, 5-L-valine-; H-His-Ser-Asp-Gly-Val-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2; Gastrointestinal peptide SCT analogue
EINECS	Contact for details

Quality Control

Our Secretin, Val(5)- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all test results against stringent in-house specifications to ensure consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by AAA)
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC)	≤ 15.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.