Description

Dl-Valine-15N is a stable isotope-labeled analog of the essential amino acid valine, where the nitrogen atom is enriched with the 15N isotope. This compound is a critical tool in advanced research, enabling precise metabolic pathway tracing, protein turnover studies, and quantitative proteomics. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic manufacturers engaged in mass spectrometry-based analysis, biomarker discovery, and the development of stable isotope-labeled internal standards.

Application

• Mass Spectrometry (MS) & Nuclear Magnetic Resonance (NMR) Standards: Serves as an internal standard for the accurate quantification of valine and related metabolites in complex biological samples.
• Metabolic Flux Analysis: Used to trace and quantify nitrogen incorporation and metabolic pathways in cell cultures, tissues, and whole organisms.
• Proteomics Research: Employed in Stable Isotope Labeling by Amino acids in Cell culture (SILAC) and other techniques for comparative protein expression profiling.
• Pharmaceutical Development: Facilitates drug metabolism and pharmacokinetic (DMPK) studies to understand the fate of nitrogen-containing drug molecules.
• Clinical Diagnostics: Used in the development of advanced diagnostic assays for inborn errors of metabolism, such as maple syrup urine disease.
• Nutritional Science Research: Applied in studies investigating protein synthesis, amino acid requirements, and whole-body nitrogen balance.

Basic Information

Item	Detail
Product Name	Dl-Valine-15N
CAS No.	71261-62-6
Molecular Formula	C5H1115NO2
Molecular Weight	118.15 g/mol (for 15N labeled form)
Synonyms	DL-Valine-15N; (±)-2-Amino-3-methylbutanoic acid-15N; Valine-15N (racemic); (RS)-2-Azanyl-3-methylbutanoic acid-15N; 2-Azaniumyl-3-methylbutanoate-15N; UNII-4PP3KGD90H; Stable Isotope Labeled DL-Valine; 15N Labeled Racemic Valine
EINECS	Contact for details

Quality Control

Every batch of Dl-Valine-15N is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high standards required for research and development. Key parameters include isotopic enrichment (Atom % 15N), chemical purity, and chiral purity. A Certificate of Analysis (COA) detailing specific results for each lot, including assay by HPLC, isotopic purity by MS, and identification by IR/NMR, is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % 15N)	≥ 98%
Optical Purity (Chiral HPLC)	Racemic mixture (DL-form)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.