Description

Glucagon, Des-His(1)-(N(Epsilon)-Phenylthiocarbamoyl-Lys(12))- is a chemically modified peptide derivative of the glucagon hormone, designed for advanced research and development applications. This compound is critical for studying glucagon receptor interactions, signal transduction pathways, and the development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies specializing in endocrinology and metabolic disease research.

Application

• Biochemical Research: Used as a key reagent in the study of glucagon receptor binding affinity and specificity.
• Drug Discovery: Serves as a reference standard or intermediate in the development of glucagon receptor antagonists or modulators for diabetes and obesity.
• Structure-Activity Relationship (SAR) Studies: Essential for investigating the impact of specific amino acid modifications on peptide hormone function and stability.
• Analytical Method Development: Employed as a calibrant or control in high-performance liquid chromatography (HPLC) and mass spectrometry (MS) methods for peptide analysis.
• Peptide Chemistry: Acts as a model compound for studying chemical modification techniques, such as selective lysine derivatization.
• Metabolic Pathway Analysis: Used in in vitro assays to dissect the molecular mechanisms of glucagon action in liver cells and other target tissues.

Basic Information

Product Name	Glucagon, Des-His(1)-(N(Epsilon)-Phenylthiocarbamoyl-Lys(12))-
CAS No.	71093-12-4
Molecular Formula	C149H226N42O49S2
Molecular Weight	~3483.9 g/mol
Synonyms	Des-His(1)-[Lys(PTC)12]-Glucagon; [Lys12(Nε-Phenylthiocarbamoyl)]-Des-His1-Glucagon; Glucagon (1-29), Des-His1-, Lys12-(Nε-phenylthiocarbamoyl)-; PTC-Lys12-Des-His1-Glucagon; Modified Glucagon Analog; Glucagon Derivative; Glucagon Receptor Probe
EINECS	Contact for details

Quality Control

Our Glucagon, Des-His(1)-(N(Epsilon)-Phenylthiocarbamoyl-Lys(12))- is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, Acetic Acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.