Description

Angiotensin I Human Acetate Hydrate is a high-purity synthetic peptide fragment corresponding to the decapeptide sequence of human angiotensin I. This compound serves as a critical biochemical tool and a key precursor in the renin-angiotensin system (RAS) research pathway. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require precise and reliable reference standards for enzyme activity studies, assay development, and drug discovery programs targeting cardiovascular and renal diseases.

Application

• Biochemical Research: Used as a specific substrate for angiotensin-converting enzyme (ACE) activity assays and kinetic studies.
• Pharmaceutical Development: Serves as a critical reference standard and intermediate in the development of cardiovascular drugs, including ACE inhibitors and angiotensin receptor blockers (ARBs).
• Diagnostic Reagent Production: Employed in the formulation of immunoassay kits (e.g., ELISA, RIA) for the quantitative measurement of renin and angiotensin-related peptides in clinical samples.
• Cell Signaling Studies: Applied in in vitro and ex vivo models to study the physiological and pathological roles of the renin-angiotensin system in blood pressure regulation and tissue remodeling.
• Quality Control: Acts as a certified reference material (CRM) for the quality assurance and validation of analytical methods in pharmaceutical quality control laboratories.

Basic Information

Product Name	Angiotensin I Human Acetate Hydrate
CAS No.	70937-97-2
Molecular Formula	C62H89N17O14 • xC2H4O2 • yH2O
Molecular Weight	~1296.5 g/mol (anhydrous free acid)
Synonyms	Angiotensin I (human); Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu; H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH; DRVYIHPFHL; Human Angiotensin I; Ang I; AI; Angiotensin I Acetate Salt; Angiotensin I Acetate Hydrate
EINECS	Contact for details

Quality Control

Our Angiotensin I Human Acetate Hydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, acetate and water content, and analytical results are provided to ensure compliance with research and development standards. We support traceability and consistency for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 70.0% (by amino acid analysis)
Water Content (KF)	≤ 10.0%
Acetate Content (IC)	5.0% - 15.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.