Description

Benzyloxycarbonyl α-Aminoisobutyryl-α-Aminoisobutyryl-n-Methylalaninamide is a specialized, protected peptide building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the construction of complex peptide sequences, particularly those requiring sterically hindered or N-methylated amino acids to modulate biological activity and stability. Pharmaceutical researchers and fine chemical manufacturers need this high-purity intermediate for developing novel therapeutic peptides, peptidomimetics, and other bioactive molecules where precise structural control is paramount.

Application

• Pharmaceutical Intermediate: Critical building block for the solid-phase and solution-phase synthesis of complex therapeutic peptides.
• Peptidomimetic Research: Used in the design and synthesis of peptidomimetics to enhance metabolic stability and bioavailability of drug candidates.
• Bioactive Peptide Synthesis: Enables the incorporation of the unique α-aminoisobutyric acid (Aib) and N-methylalanine residues, which are known to induce specific helical conformations and influence peptide-receptor interactions.
• Chemical Biology Probes: Serves as a precursor for labeled or modified peptides used in mechanistic studies and target identification.
• Custom Peptide Service: A key raw material for contract research and manufacturing organizations (CROs/CMOs) offering bespoke peptide synthesis services.
• Academic Research: Utilized in university and institutional labs for studying peptide folding, stability, and structure-activity relationships (SAR).

Basic Information

Item	Details
Product Name	Benzyloxycarbonyl α-Aminoisobutyryl-α-Aminoisobutyryl-n-Methylalaninamide
CAS No.	70904-78-8
Molecular Formula	C24H36N4O6
Molecular Weight	476.57 g/mol
Synonyms	Z-Aib-Aib-N-Me-Ala-NH2; Cbz-Aib-Aib-N-Methylalaninamide; Z-Aib-Aib-N-Me-Ala-NH2; Benzyloxycarbonyl-Aib-Aib-N-methyl-L-alaninamide; Z-Aib-Aib-N-Me-L-Ala-NH2; (S)-2-((S)-2-((((Benzyloxy)carbonyl)amino)-2-methylpropanamido)-2-methylpropanamido)-N-methylpropanamide; Nα-Carbobenzoxy-Aib-Aib-N-methyl-L-alaninamide; Protected Aib-Aib-N-Me-Ala peptide fragment
EINECS	Contact for details

Quality Control

Our Benzyloxycarbonyl α-Aminoisobutyryl-α-Aminoisobutyryl-n-Methylalaninamide is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and GMP-grade applications. We employ advanced analytical techniques including HPLC, MS, and NMR for comprehensive characterization. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.