Description

Angiotensin II, Val(5)-Trp(8)- is a synthetic peptide analog of the endogenous vasoconstrictor hormone Angiotensin II, specifically modified at positions 5 and 8. This modification is of significant research interest for studying structure-activity relationships and receptor binding profiles within the renin-angiotensin system. It serves as a critical biochemical tool for pharmaceutical R&D, academic research, and diagnostic development, particularly in cardiovascular and renal physiology studies.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of the renin-angiotensin-aldosterone system (RAAS).
• Pharmacology & Drug Discovery: A key compound for investigating Angiotensin II receptor (AT1 & AT2) interactions, selectivity, and for screening potential receptor antagonists.
• Diagnostic Development: Employed in the development and calibration of immunoassays (e.g., ELISA, RIA) for detecting Angiotensin II and related peptides.
• Cell Signaling Studies: Applied in vitro to stimulate cellular pathways and model physiological or pathophysiological conditions related to blood pressure regulation and fluid balance.
• Peptide Chemistry Reference: Serves as a model compound in peptide synthesis, purification, and analytical method development due to its specific sequence.

Basic Information

Product Name	Angiotensin II, Val(5)-Trp(8)-
CAS No.	70857-54-4
Molecular Formula	C₅₀H₇₁N₁₃O₁₂
Molecular Weight	1030.2 g/mol
Synonyms	[Val⁵, Trp⁸]-Angiotensin II; Asp-Arg-Val-Tyr-Val-His-Trp-Phe; H-Asp-Arg-Val-Tyr-Val-His-Trp-Phe-OH; Angiotensin II (5-valine, 8-tryptophan); Saralasin acetate related compound A; ATII analog; AII (5-Val, 8-Trp)
EINECS	Contact for details

Quality Control

Our Angiotensin II, Val(5)-Trp(8)- is produced under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and MS for identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and solvent residues is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.