Description

2-Chloro-4-Trifluoromethoxyphenol is a versatile halogenated phenolic intermediate of significant importance in advanced organic synthesis. Its unique structure, featuring both chloro and trifluoromethoxy substituents, makes it a valuable building block for creating molecules with enhanced biological activity and specific physical properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for compounds requiring halogenated phenolic motifs.
• Agrochemical Synthesis: Serves as a crucial precursor in the manufacture of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group often enhances lipophilicity and metabolic stability.
• Liquid Crystal Materials: Used in the development of fluorinated components for liquid crystal displays (LCDs), contributing to improved dielectric anisotropy and stability.
• Polymer Modification: Acts as a functional monomer or additive to introduce specific properties like flame retardancy or altered solubility into polymer chains.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to construct complex molecular architectures.
• Dye and Pigment Intermediate: Utilized in the synthesis of specialized dyes and pigments where halogen atoms are integral to the colorant's properties.

Basic Information

Product Name	2-Chloro-4-Trifluoromethoxyphenol
CAS No.	70783-75-4
Molecular Formula	C7H4ClF3O2
Molecular Weight	212.56 g/mol
Synonyms	2-Chloro-4-(trifluoromethoxy)phenol; 4-Trifluoromethoxy-2-chlorophenol; Phenol, 2-chloro-4-(trifluoromethoxy)-; 2-Chloro-α,α,α-trifluoro-p-cresol, O-methyl ether; 2-Chloro-4-trifluoromethoxy-1-hydroxybenzene
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Trifluoromethoxyphenol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.