Description

Enkephalin, Cys(2)-Cysnh2(5)- is a synthetic, cyclic peptide analog of the endogenous opioid peptide enkephalin, featuring a disulfide bridge between two cysteine residues and a C-terminal carboxamide modification. This engineered structure provides enhanced metabolic stability and receptor selectivity, making it a critical tool for advanced neurobiological and pharmacological research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on neuroscience, pain management, and receptor-ligand interaction studies.

Application

• Neuroscience Research: As a potent and selective ligand for studying δ-opioid (δ-OR) and mu-opioid (μ-OR) receptor subtypes in vitro and in vivo.
• Pharmacological Assay Development: Used as a reference standard in high-throughput screening (HTS) and binding assays to discover novel analgesics.
• Biochemical Studies: Investigation of peptide stability, structure-activity relationships (SAR), and signal transduction pathways.
• Drug Discovery: A key intermediate or pharmacophore model for the design of new non-addictive pain therapeutics and central nervous system (CNS) agents.
• Academic & Clinical Research: Fundamental research into the endogenous opioid system, its role in pain perception, mood, and addiction.

Basic Information

Product Name	Enkephalin, Cys(2)-Cysnh2(5)-
CAS No.	70768-44-4
Molecular Formula	C28H41N7O7S2
Molecular Weight	651.8 g/mol
Synonyms	[Cys2, Cys5]-Enkephalinamide; Cyclo(Cys-Tyr-Gly-Phe-Cys) amide; H-Cys-Tyr-Gly-Phe-Cys-NH2 (cyclic 2-5 disulfide); c[Cys-Tyr-Gly-Phe-Cys]-NH2; Cyclic Enkephalin Amide; Opioid Peptide Analog; c(DCys-Tyr-Gly-Phe-DCys)-NH2 (for D-isomer); Tyr-Gly-Gly-Phe-Met (Enkephalin) cyclic analog
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to guarantee identity, purity, and biological activity. Certificates of Analysis (COA) are available upon request, providing detailed results for HPLC purity, peptide content, amino acid analysis, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.