Description

Sincalide Ammonium (Cholecystokinin Octapeptide Ammonium) is a synthetic octapeptide analog of the gastrointestinal hormone cholecystokinin (CCK). This high-purity peptide is critical for diagnostic and research applications due to its potent biological activity. It is primarily utilized by pharmaceutical manufacturers, clinical diagnostic laboratories, and advanced life science research institutions.

Application

• Diagnostic Imaging Agent: Key component in cholescintigraphy (HIDA scans) to stimulate gallbladder contraction and assess biliary function.
• Pharmaceutical Intermediate: Used in the synthesis and development of therapeutic agents targeting gastrointestinal and central nervous system disorders.
• Biomedical Research: Essential tool for studying CCK receptor binding, signal transduction pathways, and the physiology of digestion and satiety.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and method validation in analytical laboratories.
• Clinical Studies: Employed in controlled trials to investigate pancreatic secretion, gallbladder motility, and related metabolic processes.

Basic Information

Product Name	Sincalide Ammonium
CAS No.	70706-98-8
Molecular Formula	C49H62N10O16S2 • xNH3
Molecular Weight	Approx. 1143.3 (base peptide)
Synonyms	Cholecystokinin Octapeptide (CCK-8) Ammonium Salt; Sincalide; CCK-8; SQ 19,844; Kinevac; CCK Octapeptide; Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2 Ammonium Salt
EINECS	Contact for details

Quality Control

Our Sincalide Ammonium is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing including HPLC for purity and identity, mass spectrometry (MS) for confirmation, and stringent tests for residual solvents and related substances. We provide full traceability and Certificates of Analysis (COA) compliant with cGMP guidelines for active pharmaceutical ingredients (APIs).

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Assay (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Bacterial Endotoxins	< 10.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.