Description

Substance P, Phe(7)- CAS NO 70533-68-5 is a specific, high-purity analog of the neuropeptide Substance P, where the phenylalanine residue at position 7 is highlighted. This compound is a critical research-grade biochemical used for studying neurokinin-1 (NK-1) receptor interactions and related physiological pathways. It is essential for researchers and developers in the fields of neuroscience, pharmacology, and drug discovery who require precise and reliable peptide tools for receptor binding assays, signal transduction studies, and the development of novel therapeutic agents.

Application

• Neuroscience Research: As a key tool for investigating the role of Substance P in pain transmission, neuroinflammation, and central nervous system disorders.
• Pharmacological Studies: Used in competitive binding assays and functional studies to characterize NK-1 receptor activity and antagonist efficacy.
• Drug Discovery & Development: Serves as a reference standard and active agent in screening programs for novel analgesics, anti-inflammatory, and anti-emetic drugs.
• Biochemical Assays: Employed in enzyme-linked immunosorbent assays (ELISAs) and other immunoassays for the quantification and detection of Substance P pathways.
• Cell Signaling Research: Used to stimulate and study intracellular signaling cascades mediated by G-protein coupled receptors (GPCRs).
• Academic & Institutional Research: A fundamental reagent for university and institutional labs exploring peptidergic systems and neuropeptide function.

Basic Information

Product Name	Substance P, Phe(7)- CAS NO 70533-68-5
CAS No.	70533-68-5
Molecular Formula	C63H98N18O13S
Molecular Weight	1347.6 g/mol
Synonyms	Substance P (5-11), Phe(7)-; [Phe7]-Substance P (5-11); Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2; H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2; Neurokinin P; SP (5-11), Phe7-; Substance P fragment 5-11, [Phe7]-
EINECS	Contact for details

Quality Control

Our Substance P, Phe(7)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and MS for identity confirmation, to ensure it meets the high standards required for critical research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and reliability for your scientific work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.