Description

Itazigrel is a synthetic organic compound belonging to the class of thromboxane A2 receptor antagonists. This compound is valued for its potent and selective pharmacological activity in modulating platelet aggregation and vascular tone. It is primarily utilized in advanced pharmaceutical research and development, particularly for investigating cardiovascular and thrombotic disorders. Global B2B clients source this high-purity intermediate for the synthesis of novel therapeutic agents and reference standards.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced thromboxane A2 receptor antagonist drug candidates.
• Biochemical Research: Used as a reference standard and tool compound in cardiovascular and thrombosis research studies.
• Mechanism of Action Studies: Employed to investigate platelet aggregation pathways and vascular biology in preclinical models.
• API Development: Serves as a critical precursor in the development and scale-up of active pharmaceutical ingredients (APIs) targeting thrombotic diseases.
• Analytical Standard: Provides a high-purity benchmark for quality control and method development in analytical laboratories.

Basic Information

Product Name	Itazigrel
CAS No.	70529-35-0
Molecular Formula	C17H16N2O3S
Molecular Weight	328.38 g/mol
Synonyms	Itazigrel; 4,5-Bis(4-methoxyphenyl)-2-(1H-1,2,4-triazol-1-yl)thiophene-3-carbonitrile; 4,5-Bis(p-methoxyphenyl)-2-(1H-1,2,4-triazol-1-yl)-3-thiophenecarbonitrile; 3-Thiophenecarbonitrile, 4,5-bis(4-methoxyphenyl)-2-(1H-1,2,4-triazol-1-yl)-; U 63557A; U-63557A; Thromboxane A2 antagonist U63557A
EINECS	Contact for details

Quality Control

Our Itazigrel is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Production adheres to cGMP guidelines where applicable, and each lot is supported by a comprehensive Certificate of Analysis (COA). The COA details critical parameters including assay purity, identity confirmation, and impurity profiles, providing full traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.