Description

3-Iodo-L-Tyrosine Methyl Ester is a halogenated derivative of the amino acid tyrosine, specifically modified as a methyl ester. This compound is a crucial synthetic intermediate in organic and medicinal chemistry, valued for its iodine atom which serves as a versatile handle for further chemical transformations. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel therapeutic agents, radiopharmaceuticals, and biochemical probes.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of thyroid hormone analogs and other bioactive molecules.
• Radiopharmaceutical Precursor: Used in the development of iodine-123 or iodine-131 labeled compounds for diagnostic imaging and therapy.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies, particularly those involving tyrosine kinases or iodination pathways.
• Peptide Synthesis: Incorporated into custom peptides to introduce iodine labels for tracking, binding studies, or structural analysis.
• Organic Synthesis: Versatile intermediate for cross-coupling reactions (e.g., Suzuki, Sonogashira) due to the reactive iodoaryl group.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	3-Iodo-L-Tyrosine Methyl Ester
CAS No.	70277-02-0
Molecular Formula	C10H12INO3
Molecular Weight	321.11 g/mol
Synonyms	L-Tyrosine, 3-iodo-, methyl ester; Methyl (2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoate; 3-Iodo-L-tyrosine methyl ester; Methyl 3-iodo-L-tyrosinate; (S)-Methyl 2-amino-3-(4-hydroxy-3-iodophenyl)propanoate; 3-Iodo-O-methyl-L-tyrosine; 3-I-Tyr-OMe
EINECS	Contact for details

Quality Control

Our 3-Iodo-L-Tyrosine Methyl Ester is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, IR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.