Description

Physalemin, 2-De-L-Alanine-3-De-L-Aspartic Acid-4-De-L-Proline-5-De-L-Asparagine-6-De-L-Lysine is a synthetic analog of the natural tachykinin peptide physalemin, with specific amino acid deletions that modify its biological activity and receptor binding profile. This compound is of significant value for advanced biochemical research and pharmaceutical development, particularly in the study of neurokinin receptors and related signaling pathways. It serves as a critical research tool for scientists in neuropharmacology, peptide chemistry, and drug discovery, enabling the exploration of new therapeutic targets for conditions involving inflammation and pain.

Application

• Biochemical Research: Used as a reference standard and active agent in studies investigating tachykinin receptor (NK1, NK2, NK3) pharmacology, function, and signaling mechanisms.
• Neuroscience Studies: Applied in vitro and in vivo models to examine the role of neuropeptides in pain transmission, neurogenic inflammation, and central nervous system disorders.
• Drug Discovery & Development: Serves as a key intermediate or pharmacological tool in the design and screening of novel peptide-based therapeutics targeting neurokinin pathways.
• Academic & Institutional Research: Essential for university and research institute laboratories focused on peptide structure-activity relationships (SAR) and molecular biology.
• Pharmaceutical R&D: Utilized in preclinical development for testing drug efficacy, pharmacokinetics, and safety profiles related to neurokinin receptor modulation.
• Diagnostic Development: Potential use in the development of assay kits and diagnostic reagents for research purposes related to peptide biomarkers.

Basic Information

Product Name	Physalemin, 2-De-L-Alanine-3-De-L-Aspartic Acid-4-De-L-Proline-5-De-L-Asparagine-6-De-L-Lysine
CAS No.	70082-71-2
Molecular Formula	C49H75N13O14
Molecular Weight	1046.2 g/mol
Synonyms	[Des-Ala2, Asp3, Pro4, Asn5, Lys6]-Physalemin; Physalemin (2-6)-deleted analog; Physalaemin fragment 7-11; Tachykinin peptide analog; Neurokinin receptor ligand; NK1 receptor research peptide; [Des-AA2-6]-Physalemin
EINECS	Contact for details

Quality Control

Our Physalemin analog is produced under stringent conditions to ensure the highest standards of purity and consistency, suitable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous quality testing protocols, and specifications can be tailored to meet specific research-grade or cGMP-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95%
Assay (Peptide Content)	≥80%
Water Content (KF)	≤5.0%
Single Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.