Description

Enkephalinamide-Met Sulfoxide, Ala(2)- CAS NO 70021-29-3 is a chemically modified peptide analog of the endogenous opioid peptide enkephalin, specifically featuring an alanine substitution at position 2 and the oxidation of the methionine residue to its sulfoxide form. This compound is of significant value for biochemical and pharmacological research, serving as a crucial tool for studying opioid receptor interactions, signal transduction pathways, and the metabolic stability of peptide therapeutics. It is primarily needed by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in neuroscience, pain management research, and peptide drug discovery.

Application

• Neuroscience Research: Used as a reference standard or experimental ligand in studies investigating the endogenous opioid system, receptor binding affinity, and signal modulation.
• Pharmacological Assays: Employed in in vitro and in vivo assays to evaluate analgesic effects, tolerance development, and the structure-activity relationships (SAR) of opioid peptides.
• Peptide Chemistry Studies: Serves as a model compound for investigating the effects of methionine oxidation and amino acid substitutions on peptide conformation, stability, and biological activity.
• Drug Discovery & Development: Acts as a key intermediate or analog in the design and synthesis of novel peptide-based therapeutics targeting pain and neurological disorders.
• Biochemical Tool: Utilized in enzyme inhibition studies, particularly those related to peptidases that degrade enkephalins, to develop enzyme-resistant analogs.
• Academic Research: Fundamental research tool in university laboratories for graduate and post-doctoral studies on neuropeptides and their modified forms.

Basic Information

Product Name	Enkephalinamide-Met Sulfoxide, Ala(2)- CAS NO 70021-29-3
CAS No.	70021-29-3
Molecular Formula	C28H38N6O8S
Molecular Weight	618.70 g/mol
Synonyms	H-Tyr-Ala-Gly-Phe-Met(O)-NH2; [Ala2, Met(O)5]-Enkephalinamide; Methionine Sulfoxide-Enkephalin, Ala(2)-; L-Tyrosyl-L-alanylglycyl-L-phenylalanyl-L-methionine (S-oxide) amide; Opioid peptide analog [Ala2, Met(O)5]; YAGFM(O)-NH2; (5S)-5-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-(methylsulfinyl)-1-oxobutan-2-yl]-3-(carbamoylamino)pentanamide
EINECS	Contact for details

Quality Control

Our Enkephalinamide-Met Sulfoxide, Ala(2)- is produced and tested under stringent quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant industry standards for research-grade peptides, ensuring reliable performance in your experimental systems.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.