Description

Z-Leu-Leu-Oh CAS NO 7801-71-0 is a protected dipeptide derivative, specifically the C-terminal carboxylic acid of the Z-Leu-Leu sequence. This compound serves as a crucial building block in solid-phase peptide synthesis (SPPS), enabling the controlled elongation of peptide chains. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biochemical sectors for developing novel therapeutic peptides and conducting proteomics research.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block for the controlled, sequential assembly of longer, complex peptide sequences.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs) with potential therapeutic applications.
• Biochemical Research: Employed in proteomics and enzymology studies to investigate protein-protein interactions and enzyme mechanisms.
• Protease Inhibitor Synthesis: Acts as a precursor or core structure in the synthesis of peptide-based protease inhibitors.
• Custom Peptide Production: Essential for contract research and manufacturing organizations (CROs/CMOs) producing bespoke peptides for clients.
• Academic Research: A standard reagent in university and institutional labs for teaching and advancing peptide chemistry methodologies.

Basic Information

Product Name	Z-Leu-Leu-Oh
CAS No.	7801-71-0
Molecular Formula	C20H30N2O5
Molecular Weight	378.47 g/mol
Synonyms	N-Carbobenzoxy-L-leucyl-L-leucine; Z-L-Leucyl-L-leucine; CBZ-Leu-Leu-OH; Nα-CBZ-L-leucyl-L-leucine; Benzyloxycarbonyl-L-leucyl-L-leucine; (S)-2-(((Benzyloxy)carbonyl)amino)-4-methyl-N-((S)-1-((S)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)pentanamide; Z-LL-OH; N-Cbz-L-leucyl-L-leucine
EINECS	Contact for details

Quality Control

Our Z-Leu-Leu-Oh is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurities is provided with every shipment to guarantee traceability and consistency for your research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-40° to -44° (c=1 in DMF)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.