Description

Z-Leu-Val-Oh is a protected dipeptide derivative, specifically the C-terminal carboxylic acid of the Z-Leu-Val sequence. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), enabling the controlled elongation of peptide chains. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers for the production of therapeutic peptides, research peptides, and complex organic molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental protected dipeptide unit for the sequential assembly of longer, more complex peptide sequences.
• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Biochemical Research: Used in studies of enzyme-substrate interactions, protein folding, and as a standard in analytical method development for peptide chemistry.
• Custom Peptide Manufacturing: Employed by CROs and CDMOs for the contract synthesis of specific peptide sequences for clients.
• Protecting Group Chemistry: The Z (benzyloxycarbonyl) protecting group on the N-terminus allows for selective deprotection during multi-step syntheses.

Basic Information

Product Name	Z-Leu-Val-Oh
CAS No.	7801-70-9
Molecular Formula	C₂₁H₃₂N₂O₅
Molecular Weight	392.49 g/mol
Synonyms	N-Carbobenzoxy-L-leucyl-L-valine; Z-L-Leucyl-L-valine; CBZ-Leu-Val-OH; Nα-Cbz-L-leucyl-L-valine; Benzyloxycarbonyl-L-leucyl-L-valine; (S)-2-(((Benzyloxy)carbonyl)amino)-4-methyl-N-((S)-1-isopropyl-2-oxo-2-((S)-2-oxopentan-3-yl)amino)ethyl)pentanamide; L-Valine, N-[(phenylmethoxy)carbonyl]-L-leucyl-
EINECS	Contact for details

Quality Control

Every batch of Z-Leu-Val-Oh is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure the material meets the high-purity standards required for peptide synthesis. A Certificate of Analysis (COA) detailing purity (typically ≥98% by HPLC), chiral purity, and identity is supplied with each shipment to guarantee batch-to-batch consistency and traceability for your research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.