Description

L-Proline Hydrochloride is a high-purity, crystalline salt of the amino acid L-proline, widely recognized for its critical role in peptide synthesis and biochemical research. This compound is essential for its function as a chiral building block, ensuring the correct stereochemistry in complex organic molecules. It is a fundamental raw material for pharmaceutical manufacturers, research institutions, and biotechnology companies engaged in the development of APIs, peptides, and nutritional supplements.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) and complex peptide drugs.
• Biochemical Research: Used as a standard and reagent in cell culture media, enzyme studies, and metabolic pathway analysis.
• Peptide Synthesis: Serves as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis (SPPS).
• Nutritional Supplements: Employed in the formulation of specialized amino acid supplements and nutraceuticals.
• Cosmetic Ingredients: Incorporated into skincare formulations for its role as a moisturizing agent and collagen synthesis promoter.
• Asymmetric Catalysis: Utilized as a ligand or precursor in chiral catalysts for stereoselective chemical reactions.

Basic Information

Product Name	L-Proline Hydrochloride
CAS No.	7776-34-3
Molecular Formula	C5H9NO2·HCl
Molecular Weight	151.60 g/mol
Synonyms	(S)-Pyrolidine-2-carboxylic acid hydrochloride; L-2-Pyrrolidinecarboxylic acid hydrochloride; (S)-Proline hydrochloride; Proline HCl; H-Pro-OH·HCl; L-Proline HCl; L-Proline monohydrochloride; (+)-Proline hydrochloride
EINECS	231-936-1

Quality Control

Our L-Proline Hydrochloride is manufactured under a strict quality management system. Each batch is tested to meet high-purity standards suitable for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) is provided, detailing parameters such as assay, optical rotation, and impurity profiles to ensure batch-to-batch consistency and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent caking and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Assay (HPLC)	≥98.5%
Specific Rotation [α]20/D	-84.0° to -86.0° (c=1 in H2O)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm
Related Substances (HPLC)	Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.