Description

Z-Gly-Gly-Gly-Gly-OH is a high-purity, protected tetraglycine peptide derivative, widely utilized as a critical building block in peptide synthesis and biochemical research. Its primary value lies in providing a defined, multi-glycine sequence with an N-terminal benzyloxycarbonyl (Z) protecting group, enabling precise chain elongation and modification. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who require reliable, high-quality intermediates for developing novel peptides, studying enzyme substrates, or creating specialized biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled assembly of longer peptide chains containing glycine-rich regions.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly for proteases and peptidases, to investigate specificity and kinetics.
• Pharmaceutical Development: Serves as a core fragment in the research and development of therapeutic peptides targeting various diseases.
• Material Science: Incorporated into the design of bio-inspired polymers and hydrogels to impart specific mechanical or biological properties.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in peptide analysis.
• Conjugation Chemistry: The free C-terminal carboxyl group allows for conjugation to other molecules, carriers, or surfaces for diagnostic or targeting applications.

Basic Information

Product Name	Z-Gly-Gly-Gly-Gly-OH
CAS No.	7770-50-5
Molecular Formula	C19H25N5O7
Molecular Weight	435.43 g/mol
Synonyms	Benzyloxycarbonyl-glycyl-glycyl-glycyl-glycine; Z-GGGG-OH; Nα-Carbobenzoxy-tetraglycine; CBZ-Gly-Gly-Gly-Gly-OH; N-CBZ-Gly-Gly-Gly-Gly; Tetraglycine, N-benzyloxycarbonyl-; Nα-(Benzyloxycarbonyl)tetraglycine; Z-Gly4-OH
EINECS	Contact for details

Quality Control

Our Z-Gly-Gly-Gly-Gly-OH is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR and MS for structural confirmation, and tests for residual solvents and moisture. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.