Description

H-His-Leu-Oh CAS NO 7763-65-7 is a high-purity dipeptide composed of the amino acids L-Histidine and L-Leucine. This compound serves as a critical building block and research tool in advanced biochemical and pharmaceutical development. It is essential for researchers and manufacturers in the fields of peptide synthesis, medicinal chemistry, and proteomics who require reliable, high-quality intermediates.

Application

• Pharmaceutical Intermediate: Used in the synthesis of more complex peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Biochemical Research: Acts as a standard or substrate in enzymatic studies, metabolic pathway analysis, and protein structure-function research.
• Peptide Synthesis: A fundamental building block in solid-phase and solution-phase peptide synthesis for creating custom peptide sequences.
• Proteomics & Mass Spectrometry: Employed as a reference compound or digest standard in mass spectrometry calibration and protein identification workflows.
• Cell Culture & Media Supplement: May be used as a specialized nutrient component in advanced cell culture media formulations.
• Enzyme Substrate Mimic: Useful for studying protease and peptidase activity and specificity in vitro.

Basic Information

Product Name	H-His-Leu-Oh
CAS No.	7763-65-7
Molecular Formula	C12H20N4O3
Molecular Weight	268.31 g/mol
Synonyms	L-Histidyl-L-leucine; Histidine-Leucine dipeptide; H-His-Leu-OH; L-His-L-Leu; His-Leu; N-(N-L-Histidyl)-L-leucine; 7763-65-7; L-Leucine, N-L-histidyl-
EINECS	Contact for details

Quality Control

Our H-His-Leu-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.