Description

D-Azetidine-2-Carboxylic Acid CAS NO 7729-30-8 is a non-proteinogenic amino acid featuring a unique four-membered azetidine ring, making it a valuable chiral building block and biochemical probe. This constrained structure is of significant interest for modulating peptide conformation and biological activity in advanced research and development. It serves as a critical intermediate for pharmaceutical chemists and researchers in medicinal chemistry, peptide science, and agrochemical discovery.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel drug candidates, particularly protease inhibitors and other bioactive molecules.
• Peptide Chemistry & Research: Used to introduce conformational constraints into peptide backbones to study structure-activity relationships and enhance metabolic stability.
• Medicinal Chemistry & Drug Discovery: Serves as a building block in combinatorial chemistry libraries for high-throughput screening against various biological targets.
• Biochemical Research: Employed as a probe to study amino acid metabolism, transport mechanisms, and enzyme specificity due to its structural analogy to proline.
• Agrochemical Synthesis: Intermediate in the research and development of advanced crop protection agents with novel modes of action.
• Academic & Industrial R&D: Fundamental research tool in organic synthesis and chemical biology for exploring new reaction methodologies and bioorthogonal chemistry.

Basic Information

Product Name	D-Azetidine-2-Carboxylic Acid
CAS No.	7729-30-8
Molecular Formula	C4H7NO2
Molecular Weight	101.10 g/mol
Synonyms	(R)-Azetidine-2-carboxylic acid; D-Azetidine-2-carboxylic acid; (R)-(-)-Azetidine-2-carboxylic acid; D-2-Azetidinecarboxylic acid; (2R)-Azetidine-2-carboxylic acid; Azetidine-2-carboxylic acid, D-; L-Azetidine-2-carboxylic acid enantiomer; (R)-Azetidine-2-carboxylic acid
EINECS	231-782-1

Quality Control

Our D-Azetidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specific parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.