Description

n-o-Nps-L-Glutamine is a protected derivative of the amino acid L-glutamine, featuring an o-nitrophenylsulfenyl (Nps) protecting group on the α-amino nitrogen. This compound is of significant value in peptide synthesis and organic chemistry as a key building block, allowing for the controlled introduction of glutamine residues while preventing unwanted side reactions. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of peptides, peptidomimetics, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected amino acid derivative for the sequential assembly of peptide chains.
• Solution-Phase Peptide Synthesis: Used in classical coupling strategies for constructing specific peptide sequences.
• Research & Development: A critical reagent in academic and industrial labs for studying peptide structure-activity relationships (SAR).
• Pharmaceutical Intermediates: Serves as a building block in the synthesis of potential therapeutic peptides and protein-based drugs.
• Bioconjugation Chemistry: Can be used to introduce glutamine motifs into larger molecules or surfaces for biochemical studies.
• Fine Chemical Production: Employed in the custom synthesis of complex organic molecules requiring protected glutamine.

Basic Information

Product Name	n-o-Nps-L-Glutamine
CAS No.	7685-73-6
Molecular Formula	C₁₁H₁₃N₃O₆S
Molecular Weight	315.30 g/mol
Synonyms	N-2-Nitrophenylsulfenyl-L-glutamine; L-Glutamine, N-(2-nitrophenylthio)-; o-Nps-L-Gln; N-(o-Nitrophenylsulfenyl)-L-glutamine; N-(2-Nitrophenylsulfanyl)-L-glutamine; NPS-L-Glutamine; 2-Nitrophenylsulfenyl-L-glutamine; (S)-2-Amino-4-carbamoylbutanoic acid 2-nitrophenyl sulfenamide
EINECS	Contact for details

Quality Control

Our n-o-Nps-L-Glutamine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and identity confirmation via spectroscopic methods. We provide full traceability and a Certificate of Analysis (COA) with every shipment, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.