Description

4-Fluoro-5-Hydroxynorvaline is a fluorinated, non-proteinogenic amino acid derivative of significant interest in advanced pharmaceutical and biochemical research. This compound matters as a specialized building block for the synthesis of novel peptides and enzyme inhibitors, where the fluorine atom and hydroxyl group offer unique opportunities for modulating biological activity and metabolic stability. It is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and life science sectors for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, including protease inhibitors and other bioactive molecules.
• Peptide Chemistry: Used as a modified amino acid residue in the solid-phase and solution-phase synthesis of fluorinated peptides to study structure-activity relationships.
• Biochemical Research: Serves as a substrate analog or inhibitor in enzymatic studies to investigate metabolic pathways and enzyme mechanisms.
• Agrochemical Development: Employed as a precursor in the synthesis of advanced, fluorinated active ingredients for crop protection products.
• Chemical Biology Probes: Utilized to create labeled or tagged compounds for imaging, diagnostics, and target identification studies.
• Academic & Institutional R&D: A valuable reagent for universities and research institutes exploring new synthetic methodologies and fluorine chemistry.

Basic Information

Product Name	4-Fluoro-5-Hydroxynorvaline
CAS No.	7682-61-3
Molecular Formula	C5H10FNO3
Molecular Weight	151.14 g/mol
Synonyms	5-Hydroxy-4-fluoronorvaline; (2S,4R)-4-Fluoro-5-hydroxynorvaline; 4-Fluoro-5-hydroxynorvaline; 4-Fluoro-5-hydroxy-L-norvaline; γ-Fluoro-δ-hydroxy-L-norvaline; 2-Amino-4-fluoro-5-hydroxypentanoic acid; (S,R)-4-Fluoro-5-hydroxynorvaline; 4-Fluoro-5-hydroxy-DL-norvaline
EINECS	Contact for details

Quality Control

Our 4-Fluoro-5-Hydroxynorvaline is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture, which may affect product stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.