Description

n-(2-Nitrophenylsulfenyl)-L-Asparagine (Dicyclohexylammonium) Salt is a specialized, protected amino acid derivative primarily used as a key synthetic intermediate in advanced organic and peptide chemistry. Its core value lies in enabling the controlled synthesis of complex peptides and asparagine-containing compounds by providing a reactive, selectively deprotectable functional group. This high-purity building block is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors, particularly those developing novel therapeutic peptides, peptidomimetics, and bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the solid-phase and solution-phase synthesis of therapeutic peptides and proteins.
• Peptide Research: Used in academic and industrial R&D for constructing complex peptide sequences where the selective protection of the asparagine side chain is required.
• Bioconjugation: Serves as a reagent for the site-specific modification of proteins and other biomolecules.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of specialized organic compounds, including unnatural amino acids and enzyme inhibitors.
• Protecting Group Chemistry: The 2-nitrophenylsulfenyl (Nps) group offers orthogonal protection strategies, valuable in complex multi-functional molecule assembly.

Basic Information

Product Name	n-(2-Nitrophenylsulfenyl)-L-Asparagine (Dicyclohexylammonium) Salt
CAS No.	7675-59-4
Molecular Formula	C22H34N4O5S
Molecular Weight	466.60 g/mol
Synonyms	Nps-Asn-OH·DCHA; L-Asparagine, N-[(2-nitrophenyl)thio]-, compound with dicyclohexylamine (1:1); Dicyclohexylammonium N-(2-nitrophenylsulfenyl)-L-asparaginate; N-2-Nitrophenylsulfenyl-L-asparagine dicyclohexylammonium salt; Nps-L-Asn-OH DCHA salt; NSC 334904; (2S)-2-[[(2-Nitrophenyl)sulfanyl]amino]-4-oxo-4-aminobutanoic acid - dicyclohexylamine (1:1)
EINECS	Contact for details

Quality Control

Our n-(2-Nitrophenylsulfenyl)-L-Asparagine (Dicyclohexylammonium) Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP manufacturing. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.