Description

2-Nitrobenzenesulfenyl Chloride is a specialized organosulfur reagent primarily used as a sulfenylating agent in organic synthesis. This compound is valued for its ability to introduce the 2-nitrobenzenesulfenyl (Nps) protecting group, particularly for thiols and amines, enabling selective transformations in complex molecule construction. It is an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for process development and scale-up.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for introducing sulfenyl protecting groups in the synthesis of active pharmaceutical ingredients (APIs) and complex natural products.
• Peptide Chemistry: Used for the selective protection of cysteine thiol groups during solid-phase and solution-phase peptide synthesis.
• Agrochemical Research: Serves as a precursor in the development of novel herbicides, fungicides, and insecticides with sulfur-containing motifs.
• Polymer & Material Science: Employed in the surface modification of polymers and the creation of specialty monomers with specific reactive sites.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes for studying enzyme mechanisms, particularly cysteine proteases.
• Cross-coupling Reactions: Acts as an electrophilic coupling partner in transition metal-catalyzed reactions to form carbon-sulfur bonds.

Basic Information

Product Name	2-Nitrobenzenesulfenyl Chloride
CAS No.	7669-54-7
Molecular Formula	C6H4ClNO2S
Molecular Weight	189.62 g/mol
Synonyms	o-Nitrobenzenesulfenyl Chloride; 2-Nitrobenzenesulfenyl Chloride; Nps-Cl; 2-Nitrobenzenesulphenyl Chloride; 1-Chlorosulfinyl-2-nitrobenzene; 2-Nitrothiophenol Chloride; Benzenesulfenyl chloride, 2-nitro-; (2-Nitrophenyl)sulfenyl chloride
EINECS	231-638-9

Quality Control

Our 2-Nitrobenzenesulfenyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and industrial synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C. Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	64 - 68 °C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.