Description

n-Acetyl-L-Cysteine Methyl Ester is a key derivative of the amino acid L-cysteine, specifically engineered for enhanced stability and reactivity. This compound is crucial for researchers and manufacturers requiring a protected thiol group for advanced synthesis, particularly in peptide chemistry and pharmaceutical development. It serves as a vital building block and intermediate for professionals in the pharmaceutical, biotechnology, and fine chemical sectors.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug molecules, particularly those requiring controlled thiol chemistry.
• Peptide Synthesis: Used as a protected cysteine derivative in solid-phase and solution-phase peptide synthesis to prevent unwanted disulfide bond formation during assembly.
• Bioconjugation & Protein Engineering: Facilitates site-specific labeling and modification of proteins and antibodies due to its reactive ester and protected thiol functionalities.
• Biochemical Research: Employed as a tool compound in studying enzyme mechanisms, redox biology, and cellular signaling pathways involving thiol groups.
• Antioxidant Prodrug Development: Investigated for the creation of prodrugs designed to deliver glutathione precursors or antioxidants to specific tissues.
• Cosmetic & Personal Care Actives: Serves as an intermediate in the production of advanced active ingredients targeting skin brightening and antioxidant protection.

Basic Information

Product Name	n-Acetyl-L-Cysteine Methyl Ester
CAS No.	7652-46-2
Molecular Formula	C6H11NO3S
Molecular Weight	177.22 g/mol
Synonyms	N-Acetyl-L-cysteine methyl ester; N-Acetylcysteine methyl ester; L-N-Acetylcysteine methyl ester; Methyl N-acetyl-L-cysteinate; NAC methyl ester; Ac-Cys-OMe; (2R)-2-Acetamido-3-sulfanylpropanoic acid methyl ester; S-Acetylcysteine methyl ester (related protected form)
EINECS	231-613-8

Quality Control

Our n-Acetyl-L-Cysteine Methyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm the L-configuration, and identity confirmation via IR and NMR. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with your research and cGMP-grade manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain purity and prevent hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	-30° to -35° (c=1 in methanol)
Chiral Purity (HPLC)	≥ 99.0% L-Isomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.