Description

Propargyl Methanethiosulfonate is a specialized organosulfur compound featuring both a reactive methanethiosulfonate group and a terminal alkyne moiety, making it a versatile building block for chemical synthesis. This dual functionality is critical for applications in bioconjugation, materials science, and pharmaceutical research, where it enables selective cross-linking and modification of biomolecules and polymers. It is primarily utilized by R&D chemists and process development scientists in the life sciences, agrochemical, and advanced materials sectors.

Application

• Bioconjugation Reagent: Used for site-specific labeling and cross-linking of proteins, peptides, and antibodies via cysteine residues.
• Click Chemistry Intermediate: Serves as a key precursor in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for creating complex molecular architectures.
• Polymer Modification: Enables the functionalization of polymer backbones to introduce alkyne handles for further derivatization.
• Pharmaceutical Research: Employed in the synthesis of drug candidates and prodrugs, particularly those requiring targeted delivery mechanisms.
• Agrochemical Synthesis: Acts as an intermediate in the development of novel pesticides and herbicides with specific modes of action.
• Surface Immobilization: Facilitates the covalent attachment of biomolecules to chips, beads, and other solid supports for biosensor and diagnostic applications.
• Chemical Probe Development: Used to create activity-based probes for studying enzyme function and metabolic pathways.

Basic Information

Product Name	Propargyl Methanethiosulfonate
CAS No.	7651-65-2
Molecular Formula	C4H6O2S2
Molecular Weight	150.22 g/mol
Synonyms	Propargyl Methanesulfonothioate; Methanethiosulfonic Acid Propargyl Ester; 2-Propynyl Methanethiosulfonate; Propargyl MTS; S-(2-Propynyl) Methanethiosulfonate; Propargylthio Methanesulfonate; PMTS; (Prop-2-yn-1-yl) methanesulfonothioate
EINECS	Contact for details

Quality Control

Our Propargyl Methanethiosulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated place, away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.