Description

H-Pro-Gly-Pro-Oh CAS NO 7561-51-5 is a synthetic tripeptide derivative, specifically a proline-glycine-proline sequence. This compound is of significant interest in biochemical and pharmaceutical research due to its structural role as a collagen fragment and its potential biological activity. It serves as a critical intermediate and reference standard for researchers and manufacturers in the life sciences sector. Key industries requiring this high-purity peptide include pharmaceutical R&D, cosmetic science, and advanced material development.

Application

• Pharmaceutical Research & Development: Used as a reference standard, biochemical reagent, and key intermediate in the synthesis of more complex peptide-based drugs and enzyme inhibitors.
• Cosmetic & Dermatological Science: Investigated for its potential role in collagen metabolism and skin repair, making it relevant for anti-aging and wound-healing formulations.
• Biochemical Studies: Serves as a model substrate for studying collagenase and other proteolytic enzymes, aiding in understanding tissue remodeling and degradation pathways.
• Academic & Institutional Research: Employed in universities and research institutes for fundamental studies in peptide chemistry, structural biology, and cell signaling.
• Diagnostic Development: Potential use in the development of assays and kits for detecting specific enzymatic activities or biomarkers related to collagen disorders.
• Material Science: Explored as a building block for bio-inspired materials and hydrogels due to its self-assembly properties derived from the collagen-like sequence.

Basic Information

Product Name	H-Pro-Gly-Pro-Oh
CAS No.	7561-51-5
Molecular Formula	C12H19N3O4
Molecular Weight	269.30 g/mol
Synonyms	Pro-Gly-Pro; Prolylglycylproline; PGP Tripeptide; H-Pro-Gly-Pro-OH; L-Prolyl-glycyl-L-proline; (2S)-1-[(2S)-2-[[(2S)-1-Hydroxy-5-oxopyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylic acid; Glycine, L-prolylglycyl-L-prolyl-; PGP
EINECS	Contact for details

Quality Control

Our H-Pro-Gly-Pro-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and chiral purity analysis to ensure structural integrity. We provide full traceability and detailed Certificates of Analysis (COA) for every shipment, supporting compliance with research and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.