Description

8-Chloro-Quinazoline is a versatile and high-value halogenated heterocyclic building block, essential for advanced organic synthesis. Its core quinazoline scaffold, functionalized with a reactive chlorine atom, makes it a critical intermediate for constructing complex molecules with targeted biological activity. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitor drugs targeting cancer and inflammatory diseases.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science: Used in the research and development of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Chemical Biology & Proteomics: Employed as a scaffold for designing chemical probes to study enzyme function and protein-protein interactions.
• Academic & Contract Research: Utilized in university and CRO laboratories for method development and the exploration of new synthetic pathways in heterocyclic chemistry.
• Dye & Pigment Intermediate: Acts as a starting material for synthesizing specialized quinazoline-based dyes and colorants.

Basic Information

Item	Detail
Product Name	8-Chloro-Quinazoline
CAS No.	7557-04-2
Molecular Formula	C8H5ClN2
Molecular Weight	164.59 g/mol
Synonyms	8-Chloroquinazoline; Quinazoline, 8-chloro-; 8-Chloro-1,3-diazanaphthalene; 8-Chloro-benzo[d]pyrimidine; 8-Chloro-1,3-naphthyridine (less common); 7557-04-2; 8-Cl-Quinazoline
EINECS	Contact for details

Quality Control

Our 8-Chloro-Quinazoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC-MS for impurity profiling. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications. Custom purity grades and analytical packages are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat sources and incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.