Description

Z-Gly-Leu-Nh2 is a protected dipeptide derivative, specifically the benzyloxycarbonyl (Z) protected form of Glycyl-L-leucine amide. This compound serves as a crucial building block in solid-phase peptide synthesis (SPPS), where it is used to introduce the Gly-Leu sequence while protecting the N-terminus from unwanted side reactions. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers engaged in the development of therapeutic peptides, bioactive compounds, and complex organic molecules.

Application

• Peptide Synthesis Intermediate: A key protected fragment in the stepwise construction of longer peptide chains for research and development.
• Pharmaceutical Research: Used in the discovery and synthesis of novel peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Biochemical Tool Development: Employed in the preparation of enzyme substrates, inhibitors, or probes for biochemical assays.
• Academic & Industrial R&D: Serves as a standard or starting material in organic chemistry and medicinal chemistry laboratories.
• Custom Synthesis: A fundamental component for contract research and manufacturing organizations (CROs/CMOs) producing bespoke peptides.

Basic Information

Item	Details
Product Name	Z-Gly-Leu-Nh2
CAS No.	7535-72-0
Molecular Formula	C16H23N3O4
Molecular Weight	321.37 g/mol
Synonyms	N-Benzyloxycarbonylglycyl-L-leucinamide; Z-Gly-Leu-NH2; Cbz-Gly-Leu-NH2; Benzyl N-[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]carbamoylmethylcarbamate; N-Carbobenzoxyglycyl-L-leucinamide; Glycine, N-[(benzyloxy)carbonyl]-, L-leucinamide; Z-Gly-L-Leu-NH2
EINECS	Contact for details

Quality Control

Our Z-Gly-Leu-Nh2 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a corresponding Certificate of Analysis (COA). We support compliance with cGMP guidelines for advanced research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.