Description

Methyl L-Tryptophanate Hydrochloride is a protected derivative of the essential amino acid L-Tryptophan, offering enhanced stability and solubility for advanced synthetic applications. This high-purity chiral building block is critical for researchers and manufacturers requiring precise stereochemical control in complex organic syntheses. It is primarily utilized in pharmaceutical R&D for the synthesis of peptides, peptidomimetics, and other bioactive compounds targeting neurological and metabolic pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, including peptide-based drugs and enzyme inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the tryptophan moiety while protecting the carboxylic acid group.
• Biochemical Research: Serves as a standard or reagent in metabolic pathway studies, neurotransmitter research, and protein engineering.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to construct complex molecules with high enantiomeric purity.
• Protecting Group Strategy: The methyl ester group provides a versatile protecting strategy that can be selectively cleaved under mild conditions in multi-step syntheses.

Basic Information

Product Name	Methyl L-Tryptophanate Hydrochloride
CAS No.	7524-52-9
Molecular Formula	C12H15ClN2O2
Molecular Weight	254.71 g/mol
Synonyms	L-Tryptophan methyl ester hydrochloride; (S)-2-Amino-3-(1H-indol-3-yl)propionic acid methyl ester hydrochloride; Methyl (S)-2-amino-3-(1H-indol-3-yl)propanoate hydrochloride; Tryptophan methyl ester HCl; H-Trp-OMe·HCl; Methyl L-α-amino-1H-indole-3-propionate hydrochloride; Methyl (S)-α-aminoindole-3-propionate hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl L-Tryptophanate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and fine chemical synthesis. A Certificate of Analysis (COA) detailing purity, specific rotation, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.