Description

n-(Trimethylsilyl)-L-Isoleucine Trimethylsilyl Ester is a specialized, high-purity silylated derivative of the essential amino acid L-isoleucine. This compound is critically important as a key protected intermediate in the synthesis of complex peptides and other bioactive molecules, offering enhanced solubility and stability in organic reaction media. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions engaged in advanced organic synthesis and peptide chemistry.

Application

• Peptide Synthesis: Serves as a crucial protected amino acid building block in solid-phase and solution-phase peptide synthesis (SPPS), preventing unwanted side reactions.
• Pharmaceutical Intermediates: Used in the research and development of novel therapeutic peptides and peptidomimetics.
• Chemical Derivatization: Acts as a reagent for the silylation of other sensitive compounds to improve their volatility for analytical techniques like Gas Chromatography (GC).
• Organic Synthesis: Employed as a chiral synthon in the asymmetric synthesis of complex natural products and active pharmaceutical ingredients (APIs).
• Bioconjugation Research: Utilized in studies involving the modification of biomolecules where a protected, non-reactive amino acid moiety is required.
• Reference Standard: Can be used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Item	Detail
Product Name	n-(Trimethylsilyl)-L-Isoleucine Trimethylsilyl Ester
CAS No.	7483-92-3
Molecular Formula	C15H33NO2Si2
Molecular Weight	315.60 g/mol
Synonyms	L-Isoleucine, N-(trimethylsilyl)-, trimethylsilyl ester; N,O-Bis(trimethylsilyl)-L-isoleucine; N-TMS-L-isoleucine TMS ester; (2S,3S)-2-[(Trimethylsilyl)amino]-3-methylpentanoic acid trimethylsilyl ester; N-Trimethylsilyl-L-isoleucine trimethylsilyl ester; TMS-Ile-OTMS; Protected L-Isoleucine derivative
EINECS	Contact for details

Quality Control

Our n-(Trimethylsilyl)-L-Isoleucine Trimethylsilyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification and assay by HPLC, to ensure it meets the exacting standards required for synthetic applications. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.