Description

7-Chloro-5-(2-Fluorophenyl)-1,3-Dihydro-2H-1,4-Benzodiazepin-2-One 4-Oxide is a high-purity benzodiazepine derivative and a key synthetic intermediate of significant importance in modern pharmaceutical research and development. Its value lies in its role as a critical precursor for the synthesis of advanced active pharmaceutical ingredients (APIs), enabling the production of compounds with targeted therapeutic effects. This compound is primarily needed by pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions focused on developing new central nervous system (CNS) agents and other specialized medicinal chemistry projects.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the multi-step synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new therapeutic candidates targeting neurological pathways.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling of related pharmaceutical products.
• Preclinical Studies: Utilized in the preparation of compounds for pharmacological screening and early-stage toxicology assessments.
• Custom Synthesis: A starting material for contract manufacturing organizations (CMOs) specializing in the custom synthesis of complex, high-value heterocyclic compounds.

Basic Information

Product Name	7-Chloro-5-(2-Fluorophenyl)-1,3-Dihydro-2H-1,4-Benzodiazepin-2-One 4-Oxide
CAS No.	7435-12-3
Molecular Formula	C15H10ClFN2O2
Molecular Weight	304.70 g/mol
Synonyms	7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one 4-oxide; 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-, 4-oxide; Ro 5-3027; 5-(2-Fluorophenyl)-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one 4-oxide; 7-Chloro-5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one 4-oxide
EINECS	Contact for details

Quality Control

Our 7-Chloro-5-(2-Fluorophenyl)-1,3-Dihydro-2H-1,4-Benzodiazepin-2-One 4-Oxide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) detailing batch-specific results are available upon request, providing full traceability and compliance data for your regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled and stored accordingly to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.