Description

3-Chloro-L-Tyrosine is a halogenated derivative of the essential amino acid L-Tyrosine, featuring a chlorine substituent on the aromatic ring. This modification makes it a valuable biochemical building block and research tool for studying enzyme mechanisms, protein interactions, and metabolic pathways. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for applications ranging from proteomics to the synthesis of specialized peptides and reference standards.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate in the synthesis of novel drug candidates and as a probe for studying tyrosine-related biochemical processes.
• Proteomics & Biochemical Studies: Used as a stable, halogenated analog to investigate protein structure, function, and post-translational modifications like phosphorylation.
• Enzyme Substrate & Inhibitor Studies: Acts as a substrate or inhibitor for enzymes such as tyrosine hydroxylase, tyrosine kinases, and phosphatases to elucidate their activity and regulation.
• Metabolic Pathway Analysis: Employed in tracer studies to explore the biosynthesis and catabolism of catecholamines and other tyrosine-derived metabolites.
• Reference Standard & Calibration: Used as a high-purity analytical standard in HPLC, LC-MS, and other chromatographic methods for quality control and method validation.
• Peptide Synthesis: Incorporated into custom peptides to introduce specific chemical handles or to modulate peptide properties for research and diagnostic applications.

Basic Information

Product Name	3-Chloro-L-Tyrosine
CAS No.	7423-93-0
Molecular Formula	C9H10ClNO3
Molecular Weight	215.63 g/mol
Synonyms	L-3-Chlorotyrosine; (2S)-2-Amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid; 3-Chlorotyrosine; 3-Cl-Tyr; 3-Chloro-4-hydroxy-L-phenylalanine
EINECS	Contact for details

Quality Control

Our 3-Chloro-L-Tyrosine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including identity confirmation by IR and NMR, purity assessment by HPLC, and specific tests for related substances and residual solvents. A Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	-10.0° to -15.0° (c=1 in 1N HCl)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.