Description

Methyl L-Histidinate Dihydrochloride is a high-purity, protected amino acid derivative essential for advanced peptide synthesis and biochemical research. This compound serves as a critical building block, offering enhanced stability and reactivity for the controlled introduction of the histidine moiety into complex molecular structures. It is primarily utilized by pharmaceutical R&D teams, peptide manufacturers, and academic laboratories developing novel therapeutic agents, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of L-histidine into peptide chains, particularly for research-scale and GMP-grade API production.
• Pharmaceutical Intermediate: Used in the synthesis of potential drug candidates, including enzyme inhibitors, receptor agonists/antagonists, and bioactive peptides.
• Bioconjugation & Probe Development: Serves as a precursor for labeling reagents and affinity tags in the development of diagnostic assays and imaging agents.
• Biochemical Research: Employed in studies of enzyme mechanisms, metal-binding sites, and protein structure-function relationships due to the unique properties of the histidine side chain.
• Custom Peptide Services: A fundamental reagent for CROs and CDMOs offering bespoke peptide manufacturing for clients in drug discovery.

Basic Information

Product Name	Methyl L-Histidinate Dihydrochloride
CAS No.	7389-87-9
Molecular Formula	C7H14N3O2 · 2HCl
Molecular Weight	268.12 g/mol
Synonyms	L-Histidine methyl ester dihydrochloride; Histidine methyl ester hydrochloride; Methyl (2S)-2-amino-3-(1H-imidazol-5-yl)propanoate dihydrochloride; H-His-OMe·2HCl; Methyl L-histidine ester dihydrochloride; (S)-Methyl 2-amino-3-(1H-imidazol-4-yl)propanoate dihydrochloride; Fmoc-His(Trt)-OH methyl ester precursor
EINECS	Contact for details

Quality Control

Our Methyl L-Histidinate Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the stringent requirements for peptide synthesis and pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.