Description

L-(-)-Threo-3-Hydroxyaspartic Acid is a non-proteinogenic amino acid derivative of aspartic acid, featuring an additional hydroxyl group on the β-carbon. This unique chiral structure makes it a valuable chiral building block and biochemical tool for advanced research and synthesis. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications in medicinal chemistry, enzyme studies, and the development of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and synthesis of potential drug candidates, particularly for neurological and metabolic targets.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, especially those involving aspartate aminotransferases and other enzymes metabolizing acidic amino acids.
• Neuroscience Research: Investigated for its role and analogs in glutamate receptor (NMDA) modulation and neurotransmission studies.
• Peptide Synthesis: Incorporated into synthetic peptides to introduce conformational constraints or specific bioactivity due to its hydroxylated side chain.
• Metabolic Pathway Analysis: Employed as a tracer or standard in metabolic flux analysis and studies of amino acid metabolism.
• Fine Chemical Synthesis: Acts as a starting material or intermediate for the preparation of more complex, high-value chiral molecules.

Basic Information

Product Name	L-(-)-Threo-3-Hydroxyaspartic Acid
CAS No.	7298-99-9
Molecular Formula	C4H7NO6
Molecular Weight	165.10 g/mol
Synonyms	(2S,3S)-3-Hydroxyaspartic Acid; L-threo-3-Hydroxyaspartate; (2S,3S)-2-Amino-3-hydroxysuccinic Acid; β-Hydroxy-L-aspartic Acid; L-3-Hydroxyaspartic Acid; HOAsp; 3-Hydroxy-L-aspartic Acid; L-erythro-3-Hydroxyaspartic Acid (obsolete but related)
EINECS	Contact for details

Quality Control

Our L-(-)-Threo-3-Hydroxyaspartic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and synthesis. A detailed Certificate of Analysis (COA) providing purity, identification, and impurity profile data is available for every lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-threo isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.