Description

n-[[5-(Dimethylamino)-1-Naphthyl]Sulphonyl]-L-Histidine is a specialized, high-purity chemical building block that serves as a critical intermediate in advanced pharmaceutical synthesis and biochemical research. Its unique structure, combining a dansyl-like fluorophore with the amino acid histidine, makes it invaluable for the development of enzyme inhibitors, fluorescent probes, and targeted molecular conjugates. This compound is essential for R&D and production teams in the pharmaceutical, biotechnology, and life science sectors seeking to create novel diagnostic agents or therapeutic candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting enzymatic pathways where histidine residues play a crucial role.
• Fluorescent Probe Development: Utilized to create sensitive fluorescent tags and sensors for biochemical assays, leveraging the dansyl group's strong fluorescence properties.
• Enzyme Inhibitor Research: Serves as a scaffold for designing and testing potential inhibitors for histidine-utilizing enzymes, such as certain proteases and transferases.
• Bioconjugation & Labeling: Used to label peptides, proteins, or other biomolecules for detection, purification, or imaging applications in diagnostic development.
• Biochemical Research Reagent: Employed in academic and industrial laboratories for studying protein-protein interactions, signal transduction, and other molecular biology processes.

Basic Information

Product Name	n-[[5-(Dimethylamino)-1-Naphthyl]Sulphonyl]-L-Histidine
CAS No.	7293-13-2
Molecular Formula	C18H22N4O4S
Molecular Weight	390.46 g/mol
Synonyms	L-Histidine, N-[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]-; Dansyl-L-histidine; DNS-His; 1-Dimethylaminonaphthalene-5-sulfonylhistidine; N-Dansyl-L-histidine; N-(5-Dimethylaminonaphthalene-1-sulfonyl)-L-histidine; 5-(Dimethylamino)naphthalene-1-sulfonyl-L-histidine
EINECS	Contact for details

Quality Control

Our n-[[5-(Dimethylamino)-1-Naphthyl]Sulphonyl]-L-Histidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as purity, identity, and impurity profiles. For customers with specific regulatory needs, we can discuss compliance with relevant standards on a project basis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider inert atmosphere conditions to prevent potential oxidation.

Specification

Item	Specification
Appearance	Light yellow to yellow powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.