Description

Dantrolene CAS NO 7261-97-4 is a direct-acting skeletal muscle relaxant that functions by inhibiting calcium release from the sarcoplasmic reticulum. This mechanism of action makes it a critical pharmaceutical active ingredient for managing conditions associated with muscle hypertonia and spasticity. It is primarily utilized by the pharmaceutical industry for the formulation of injectable and oral medications, as well as by research institutions for pharmacological studies.

Application

• Pharmaceutical Manufacturing: Primary active ingredient in oral capsules and intravenous formulations for the treatment of malignant hyperthermia and chronic spasticity.
• Neuromuscular Research: Used as a key pharmacological tool in laboratory studies to investigate calcium signaling and muscle contraction mechanisms.
• Hospital & Clinical Use: Essential component in emergency drug supplies for the acute management of malignant hyperthermia crisis during anesthesia.
• Veterinary Medicine: Applied in equine and other veterinary practices for the management of exertional rhabdomyolysis and related muscle disorders.
• Reference Standard: Serves as a high-purity chemical standard for quality control and analytical method development in regulatory and testing laboratories.

Basic Information

Product Name	Dantrolene
CAS No.	7261-97-4
Molecular Formula	C14H10N4O5
Molecular Weight	314.25 g/mol
Synonyms	Dantrolene Sodium (common salt form); 1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione; Dantrium® (brand name); F-368; Dantamacrin; Dantrolenum; NSC 335831
EINECS	230-661-2

Quality Control

Our Dantrolene is manufactured under strict quality management systems. Each batch is tested to ensure it meets stringent specifications for identity, purity, and potency, aligning with pharmacopeial standards. A comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and microbiological attributes is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Yellow to orange, crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.