Description

16-Acetylgitoxin is a chemically modified cardiac glycoside derivative, specifically an acetylated form of gitoxin. This compound is a critical intermediate and reference standard in pharmaceutical research and development, particularly for the study of cardiotonic agents. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who are developing or analyzing heart failure medications and studying structure-activity relationships of digitalis-like compounds.

Application

• Pharmaceutical Reference Standard: Used as a high-purity analytical standard for quality control and method validation in the production of cardiac drugs.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key synthetic precursor in the manufacture of more complex cardiotonic agents.
• Biochemical Research: Employed in pharmacological studies to investigate the mechanisms of sodium-potassium ATPase inhibition and cardiac contractility.
• Metabolite Studies: Utilized in research to understand the metabolic pathways and biotransformation of digitalis glycosides.
• Analytical Method Development: Critical for developing and calibrating HPLC, LC-MS, and other chromatographic assays for cardiac glycosides.

Basic Information

Product Name	16-Acetylgitoxin
CAS No.	7242-40-2
Molecular Formula	C₄₃H₆₆O₁₄
Molecular Weight	807.0 g/mol
Synonyms	16-Acetyl Gitoxin; 16-Acetyl-3β,14,16β-trihydroxy-5β-card-20(22)-enolide; 3β,14,16β-Trihydroxy-5β-card-20(22)-enolide 16-acetate; Gitoxin 16-acetate; 16-O-Acetylgitoxin; Acetylgitoxin; 16-Acetyl-gitoxin; 16-Acetyl-gitoxine
EINECS	Contact for details

Quality Control

Our 16-Acetylgitoxin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with detailed chromatograms and full traceability. The product meets high-purity standards suitable for pharmaceutical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.