Description

Pyrimidine, 5-(Trifluoromethyl)-2,4-Bis[(Trimethylsilyl)Oxy]- is a high-value, protected intermediate featuring a reactive pyrimidine core functionalized with a trifluoromethyl group and silyl ether protecting groups. This compound is critical for the synthesis of complex fluorinated heterocycles, offering a strategic building block for introducing both fluorine and masked hydroxyl functionalities. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries to accelerate the discovery and scalable production of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated antiviral, anticancer, and central nervous system (CNS) active drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for creating novel fluorinated organic electronic materials and liquid crystals.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs for the bespoke synthesis of complex molecules for client projects.
• Academic & R&D Laboratories: A valuable reagent for methodological studies in organic synthesis, particularly in cross-coupling and deprotection chemistry.

Basic Information

Product Name	Pyrimidine, 5-(Trifluoromethyl)-2,4-Bis[(Trimethylsilyl)Oxy]-
CAS No.	7057-43-4
Molecular Formula	C11H21F3N2O2Si2
Molecular Weight	314.47 g/mol
Synonyms	2,4-Bis(trimethylsiloxy)-5-(trifluoromethyl)pyrimidine; 5-(Trifluoromethyl)-2,4-pyrimidinediol bis(trimethylsilyl) ether; 5-Trifluoromethyl-2,4-bis(trimethylsiloxy)pyrimidine; NSC 338243; 2,4-Bis-O-(trimethylsilyl)-5-trifluoromethylpyrimidine; 5-(Trifluoromethyl)pyrimidine-2,4-diol bis(trimethylsilyl) ether
EINECS	Contact for details

Quality Control

Every batch of Pyrimidine, 5-(Trifluoromethyl)-2,4-Bis[(Trimethylsilyl)Oxy]- is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency for your critical synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, typically including results from HPLC, NMR, and GC analysis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term stability and to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.