Description

L-Histidine Monohydrochloride Monohydrate is a high-purity, crystalline amino acid salt essential for numerous biochemical and industrial processes. Its primary value lies in providing a stable, readily soluble form of the critical amino acid L-Histidine, which is vital for protein synthesis and metabolic functions. This product is indispensable for manufacturers in the pharmaceutical, nutraceutical, and food & beverage industries, where it serves as a key ingredient in infusion solutions, dietary supplements, and flavor enhancers. CAS No. 7048-02-4.

Application

• Pharmaceutical Intermediates & APIs: Used in the synthesis of active pharmaceutical ingredients (APIs) and as a component in parenteral nutrition and electrolyte solutions.
• Dietary Supplements & Sports Nutrition: A fundamental ingredient in amino acid blends, protein powders, and performance-enhancing supplements due to its role in muscle metabolism.
• Food & Beverage Fortification: Employed as a nutritional additive to enhance the protein quality of foods and as a precursor for flavor compounds.
• Cell Culture Media: An essential component of defined media for the cultivation of mammalian and bacterial cells in biopharmaceutical production.
• Biochemical Research & Diagnostics: Serves as a standard and reagent in enzymatic assays, chromatography, and various life science research applications.
• Cosmetic Formulations: Incorporated into skincare products for its purported antioxidant and skin-conditioning properties.

Basic Information

Product Name	L-Histidine Monohydrochloride Monohydrate
CAS No.	7048-02-4
Molecular Formula	C6H9N3O2 • HCl • H2O
Molecular Weight	209.63 g/mol
Synonyms	L-Histidine HCl Monohydrate; Histidine Hydrochloride Monohydrate; (S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid hydrochloride monohydrate; H-His-OH•HCl•H2O; L-Histidine, monohydrochloride, monohydrate; Histidine monohydrochloride; L-Histidine HCl H2O; L-Histidine hydrochloride hydrate
EINECS	230-305-6

Quality Control

Our L-Histidine Monohydrochloride Monohydrate is manufactured under strict quality management systems. Each batch is tested to ensure compliance with relevant pharmacopeial standards such as USP, EP, and JP, as well as food-grade specifications like FCC. We provide comprehensive Certificates of Analysis (COA) for every shipment, detailing purity, identity, and impurity profiles to guarantee batch-to-batch consistency and traceability for your regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption and caking. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms
Identification (Chloride)	Conforms
Assay (on dried basis)	98.5% - 101.0%
Specific Rotation [α]20/D	+8.5° to +10.5°
pH (5% solution)	3.0 - 5.0
Loss on Drying	7.0% - 9.0%
Residue on Ignition (Sulfated Ash)	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 0.5%
Chloride Content (as Cl)	16.5% - 17.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.