Description

4,6-Dichloro-2-Cyclopropylpyrimidine is a high-purity, halogenated pyrimidine derivative serving as a critical building block in advanced organic synthesis. Its value lies in its versatile reactivity, where the chlorine atoms and the cyclopropyl substituent provide distinct handles for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for antiviral, anticancer, and kinase inhibitor drugs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its pyrimidine core.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Material Science: Potential building block for creating specialty polymers, liquid crystals, or organic electronic materials.
• Cross-Coupling Reactions: The chlorine atoms make it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination.
• Nucleophilic Substitution: Used to introduce the cyclopropylpyrimidine moiety into more complex molecules via displacement of the chlorines.

Basic Information

Product Name	4,6-Dichloro-2-Cyclopropylpyrimidine
CAS No.	7043-09-6
Molecular Formula	C7H6Cl2N2
Molecular Weight	189.04 g/mol
Synonyms	2-Cyclopropyl-4,6-dichloropyrimidine; 4,6-Dichloro-2-cyclopropyl-pyrimidine; 2-Cyclopropyl-4,6-dichloro-pyrimidine; Pyrimidine, 4,6-dichloro-2-cyclopropyl-; 4,6-Dichloro-2-(cyclopropyl)pyrimidine; 4,6-Dichloro-2-cyclopropyl-1,3-diazine
EINECS	Contact for details

Quality Control

Our 4,6-Dichloro-2-Cyclopropylpyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.