Description

5-Pyrimidinecarboxylic Acid, 4-Phenoxy-2-(Trifluoromethyl)-, Ethyl Ester is a high-value, multi-functional heterocyclic building block characterized by its pyrimidine core and trifluoromethyl group. This compound matters for its role as a critical intermediate in the synthesis of advanced active pharmaceutical ingredients (APIs) and agrochemicals, where its unique structure imparts desirable biological and physicochemical properties. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with enhanced efficacy and stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethylpyrimidine moiety.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its aromatic and fluorinated structure.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or labeling agent in the design of chemical probes and enzyme inhibitors for target validation studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific synthetic routes and scale-up projects.

Basic Information

Product Name	5-Pyrimidinecarboxylic Acid, 4-Phenoxy-2-(Trifluoromethyl)-, Ethyl Ester
CAS No.	796-80-5
Molecular Formula	C14H11F3N2O3
Molecular Weight	312.25 g/mol
Synonyms	Ethyl 4-phenoxy-2-(trifluoromethyl)pyrimidine-5-carboxylate; 4-Phenoxy-2-trifluoromethyl-pyrimidine-5-carboxylic acid ethyl ester; 2-(Trifluoromethyl)-4-phenoxy-5-pyrimidinecarboxylic acid ethyl ester; 4-Phenoxy-2-(trifluoromethyl)pyrimidine-5-carboxylic Acid Ethyl Ester; 796-80-5; UNII-6U4J3C1W6P
EINECS	Contact for details

Quality Control

Our 5-Pyrimidinecarboxylic Acid, 4-Phenoxy-2-(Trifluoromethyl)-, Ethyl Ester is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.