Description

4-Amino-2-(Trifluoromethyl)Pyrimidine-5-Carboxylic Acid is a high-purity, multi-functional pyrimidine derivative, serving as a critical building block in advanced organic synthesis. Its unique trifluoromethyl-substituted structure offers enhanced metabolic stability and lipophilicity, making it a valuable intermediate for creating novel active compounds. This product is essential for research and development in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of antiviral, anticancer, and kinase inhibitor drugs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and fungicides, leveraging the bioactivity of the pyrimidine core.
• Material Science Research: Serves as a precursor for functionalized heterocyclic compounds used in organic electronic materials.
• Chemical Biology & Proteomics: Employed as a building block for designing molecular probes and enzyme inhibitors.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the scalable production of client-specific target molecules.

Basic Information

Product Name	4-Amino-2-(Trifluoromethyl)Pyrimidine-5-Carboxylic Acid
CAS No.	777-43-5
Molecular Formula	C6H4F3N3O2
Molecular Weight	207.11 g/mol
Synonyms	5-Pyrimidinecarboxylic acid, 4-amino-2-(trifluoromethyl)-; 4-Amino-2-trifluoromethylpyrimidine-5-carboxylic acid; 2-(Trifluoromethyl)-4-aminopyrimidine-5-carboxylic acid; 4-Amino-2-(trifluoromethyl)-5-pyrimidinecarboxylic acid; 777-43-5; ATFPC Acid
EINECS	Contact for details

Quality Control

Every batch of 4-Amino-2-(Trifluoromethyl)Pyrimidine-5-Carboxylic Acid is manufactured under a strict quality management system. Our products undergo rigorous quality testing, including HPLC and NMR analysis, to ensure compliance with industry standards and customer-specific requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.