Description

2,3,4,5,6-Pentafluoroaniline is a highly fluorinated aromatic amine building block of significant commercial importance. Its unique structure, featuring a perfluorinated benzene ring, makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients. This compound is essential for manufacturers in the agrochemical, pharmaceutical, and specialty chemical sectors. It is supplied under strict quality control to ensure reliability for demanding synthetic applications.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs) and drug candidates, leveraging fluorine's metabolic stability and bioavailability-enhancing properties.
• Agrochemical Synthesis: Used in the production of advanced, high-performance herbicides, fungicides, and pesticides where the pentafluorophenyl group imparts improved lipophilicity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, where fluorine atoms help tune dielectric anisotropy and improve thermal and chemical stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance chemical resistance, reduce surface energy, and improve weatherability for high-performance coatings and films.
• Dye & Pigment Intermediate: Used in the synthesis of specialized fluorinated dyes and pigments that offer unique color fastness and spectral properties.
• Cross-coupling Reagent: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) to create complex fluorinated aromatic amines.

Basic Information

Product Name	2,3,4,5,6-Pentafluoroaniline
CAS No.	771-60-8
Molecular Formula	C6H2F5N
Molecular Weight	183.08 g/mol
Synonyms	Pentafluoroaniline; Perfluoroaniline; 2,3,4,5,6-Pentafluorobenzenamine; Benzenamine, 2,3,4,5,6-pentafluoro-; PFA; 2,3,4,5,6-Pentafluorophenylamine; NSC 9245; AI3-24200
EINECS	212-236-0

Quality Control

Our 2,3,4,5,6-Pentafluoroaniline is manufactured under a cGMP-compliant quality management system. Every batch undergoes rigorous analytical testing to ensure it meets the highest standards of purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment. We support compliance with global regulatory frameworks including REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. Due to its light-sensitive nature, containers should be amber glass or suitably opaque.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or crystalline mass
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.