Description

5-Pyrimidinecarboxylic Acid, 4-(o-Chloroanilino)-2-(Trifluoromethyl)-, Ethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its specific pyrimidine core structure. This compound is critical for research and development in medicinal chemistry, particularly for synthesizing novel active pharmaceutical ingredients (APIs) with targeted biological activity. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly those targeting specific enzyme pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Agrochemical Development: Potential application as an intermediate in the research and synthesis of new generation herbicides or fungicides.
• Chemical Synthesis: Employed in academic and industrial laboratories for the development of complex heterocyclic compounds.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	5-Pyrimidinecarboxylic Acid, 4-(o-Chloroanilino)-2-(Trifluoromethyl)-, Ethyl Ester
CAS No.	742-37-0
Molecular Formula	C14H11ClF3N3O2
Molecular Weight	345.70 g/mol
Synonyms	Ethyl 4-[(2-chlorophenyl)amino]-2-(trifluoromethyl)pyrimidine-5-carboxylate; 4-(2-Chloroanilino)-2-(trifluoromethyl)-5-pyrimidinecarboxylic Acid Ethyl Ester; 4-(o-Chloroanilino)-2-(trifluoromethyl)pyrimidine-5-carboxylic Acid Ethyl Ester; 742-37-0; UNII-9M9K6H8F0R; 9M9K6H8F0R; Ethyl 4-(2-chloroanilino)-2-(trifluoromethyl)pyrimidine-5-carboxylate
EINECS	Contact for details

Quality Control

Our 5-Pyrimidinecarboxylic Acid, 4-(o-Chloroanilino)-2-(Trifluoromethyl)-, Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.