Description

Ethyl 4-Chloro-2-(Trifluoromethyl)Pyrimidine-5-Carboxylate is a high-value pyrimidine derivative and a versatile synthetic building block in advanced organic chemistry. Its core value proposition lies in its trifluoromethyl and chloro substituents, which are critical for modulating the biological activity and physicochemical properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, serving as a key intermediate in the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and antiviral therapies.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its unique electronic properties.
• Chemical Biology & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and fragment-based drug discovery to explore novel chemical space.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis organizations (CSOs) and CDMOs producing tailored compounds for client R&D programs.

Basic Information

Product Name	Ethyl 4-Chloro-2-(Trifluoromethyl)Pyrimidine-5-Carboxylate
CAS No.	720-01-4
Molecular Formula	C8H6ClF3N2O2
Molecular Weight	254.59 g/mol
Synonyms	Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate; 5-Pyrimidinecarboxylic acid, 4-chloro-2-(trifluoromethyl)-, ethyl ester; 4-Chloro-2-trifluoromethyl-pyrimidine-5-carboxylic acid ethyl ester; Ethyl 4-chloro-2-(trifluoromethyl)-5-pyrimidinecarboxylate; 720-01-4; NSC 163066
EINECS	Contact for details

Quality Control

Our Ethyl 4-Chloro-2-(Trifluoromethyl)Pyrimidine-5-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.