Description

4,6-Dichloro-5-Nitro-2-(Trifluoromethyl)Pyrimidine is a high-value, multi-functional heterocyclic building block characterized by its reactive halogen and nitro substituents. This compound is essential for advanced organic synthesis, particularly in the development of complex molecules for the life sciences. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for antiviral and anticancer agents.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides by serving as a core pyrimidine scaffold.
• Material Science Research: Employed in the development of specialty chemicals, dyes, and advanced polymeric materials.
• Cross-Coupling Reactions: The chlorine atoms make it a suitable substrate for palladium-catalyzed reactions like Suzuki and Buchwald-Hartwig couplings.
• Nucleophilic Aromatic Substitution: The electron-deficient ring facilitates displacement reactions with amines and alkoxides to create diverse pyrimidine libraries.
• Fluorinated Compound Development: The trifluoromethyl group provides metabolic stability and lipophilicity, making it valuable for designing bioactive molecules.

Basic Information

Product Name	4,6-Dichloro-5-Nitro-2-(Trifluoromethyl)Pyrimidine
CAS No.	715-46-8
Molecular Formula	C5HCl2F3N3O2
Molecular Weight	261.98 g/mol
Synonyms	2-(Trifluoromethyl)-4,6-dichloro-5-nitropyrimidine; 4,6-Dichloro-5-nitro-2-trifluoromethylpyrimidine; 5-Nitro-4,6-dichloro-2-(trifluoromethyl)pyrimidine; Pyrimidine, 4,6-dichloro-5-nitro-2-(trifluoromethyl)-; DNTP; 715-46-8 (CAS)
EINECS	Contact for details

Quality Control

Every batch of 4,6-Dichloro-5-Nitro-2-(Trifluoromethyl)Pyrimidine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for research and scale-up. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.